Multiple Choice
In aerobic glycolysis of one molecule of glucose to two molecules of pyruvate, what is the net production of ATP (accounting for ATP used and produced by substrate-level phosphorylation)?
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Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Glycolysis 1
Multiple Choice
Which of the following is the primary net product of glycolysis per molecule of glucose under aerobic conditions?
A
1 lactate, net 2 ATP, and 0 NADH
B
6 units as ribose-5-phosphate and 2 NADPH
C
2 acetyl-CoA, net 2 ATP, and 2 NADH
D
2 pyruvate, net 2 ATP, and 2 NADH
Verified step by step guidance1
Step 1: Understand the overall process of glycolysis. Glycolysis is the metabolic pathway that breaks down one molecule of glucose (a 6-carbon sugar) into two molecules of pyruvate (each with 3 carbons), producing energy in the form of ATP and reducing equivalents in the form of NADH.
Step 2: Recall the net energy yield of glycolysis under aerobic conditions. Glycolysis produces a net gain of 2 ATP molecules per glucose because 4 ATP are produced but 2 ATP are consumed during the initial steps.
Step 3: Identify the reducing equivalents produced. During glycolysis, 2 molecules of NAD+ are reduced to 2 molecules of NADH per glucose molecule, which can later be used in the electron transport chain under aerobic conditions.
Step 4: Recognize the primary carbon-containing products. The end product of glycolysis is 2 molecules of pyruvate, which can then enter the mitochondria for further oxidation under aerobic conditions.
Step 5: Compare the options given with the known glycolysis products. The correct primary net products per glucose molecule under aerobic conditions are 2 pyruvate, net 2 ATP, and 2 NADH.
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