The special shape on an enzyme where the substrate binds to it is the _____.

Define the active site: The active site is the specific region on the enzyme where the substrate binds. It has a unique shape and chemical properties that complement the substrate, allowing for precise binding and catalysis.

Differentiate between the options: The regulatory domain is involved in controlling enzyme activity, the cofactor pocket binds non-protein molecules that assist enzyme function, and the allosteric site is a region where molecules bind to regulate enzyme activity indirectly. None of these are the primary binding site for the substrate.