Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

Biochemistry

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

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Multiple Choice

The induced fit model of enzyme catalysis states that __________.

the substrate must have a rigid, complementary shape to the enzyme's active site

the enzyme's active site is unchanged by substrate binding

the enzyme and substrate form a covalent bond during catalysis

the enzyme changes its shape upon substrate binding to better fit the substrate

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Verified step by step guidance

Understand the concept of the induced fit model: This model explains how enzymes interact with substrates. Unlike the lock-and-key model, the induced fit model suggests that the enzyme's active site is flexible and changes shape upon substrate binding to better accommodate the substrate.

Recognize the key feature of the induced fit model: The enzyme undergoes a conformational change when the substrate binds. This change enhances the enzyme's ability to catalyze the reaction by stabilizing the transition state.

Compare the induced fit model to other models: For example, the lock-and-key model assumes a rigid active site that perfectly matches the substrate's shape, while the induced fit model emphasizes flexibility and dynamic interaction.

Identify the incorrect statements in the options: The substrate does not need to have a rigid, complementary shape, the enzyme's active site is not unchanged, and covalent bonding between enzyme and substrate is not a general feature of catalysis.

Conclude that the correct answer aligns with the induced fit model: The enzyme changes its shape upon substrate binding to better fit the substrate, which is the defining characteristic of this model.