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Multiple Choice
Which of the following amino acids is most likely to be found in the alpha-helix region of a GPCR signaling protein?
A
Glycine (Gly, G)
B
Cysteine (Cys, C)
C
Proline (Pro, P)
D
Alanine (Ala, A)
Verified step by step guidance
1
Understand the structural role of alpha-helices in GPCR signaling proteins: Alpha-helices are common secondary structures in proteins, particularly in transmembrane regions of GPCRs. They are stabilized by hydrogen bonds and require amino acids that promote helical formation.
Analyze the properties of the given amino acids: Glycine is small and flexible, which can disrupt the regular structure of an alpha-helix. Cysteine can form disulfide bonds, which are not conducive to alpha-helix formation. Proline introduces a kink in the helix due to its rigid cyclic structure, making it unfavorable for alpha-helices.
Consider Alanine's properties: Alanine is a small, nonpolar amino acid with a methyl side chain. Its structure is ideal for alpha-helix formation because it does not introduce steric hindrance or disrupt hydrogen bonding patterns.
Recall the general preference of amino acids in alpha-helices: Amino acids like alanine, leucine, and glutamate are commonly found in alpha-helices due to their ability to stabilize the structure without introducing disruptions.
Conclude that Alanine is the most likely amino acid to be found in the alpha-helix region of a GPCR signaling protein, based on its structural compatibility and frequent occurrence in alpha-helices.