Multiple Choice
In mitochondrial oxidative phosphorylation, does the electron transport chain (ETC) require oxygen to function as it normally does, and why?
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Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation
Oxidative Phosphorylation 1
Multiple Choice
In aerobic metabolism of one molecule of glucose in a eukaryotic cell, which pathway produces the greatest amount of ATP (directly and/or via NADH/FADH delivered to the electron transport chain)?
A
Pentose phosphate pathway
B
Citric acid cycle (Krebs cycle) substrate-level phosphorylation
C
Glycolysis
D
Oxidative phosphorylation (electron transport chain and ATP synthase)
Verified step by step guidance1
Identify all the major metabolic pathways involved in aerobic glucose metabolism: glycolysis, the citric acid cycle (Krebs cycle), the pentose phosphate pathway, and oxidative phosphorylation (electron transport chain and ATP synthase).
Understand the ATP yield from each pathway: glycolysis produces ATP directly and generates NADH; the citric acid cycle produces some ATP directly via substrate-level phosphorylation and generates NADH and FADH2; the pentose phosphate pathway primarily generates NADPH and does not contribute significantly to ATP production.
Recognize that NADH and FADH2 produced in glycolysis and the citric acid cycle donate electrons to the electron transport chain, which drives oxidative phosphorylation to produce the majority of ATP.
Recall that oxidative phosphorylation uses the proton gradient generated by electron transport to power ATP synthase, resulting in the highest ATP yield per glucose molecule compared to other pathways.
Conclude that among the listed options, oxidative phosphorylation produces the greatest amount of ATP both directly and indirectly via NADH and FADH2 delivered to the electron transport chain.
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