Multiple Choice
What is the major difference between paracrine and endocrine signaling?
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12. Biosignaling
Lipid Hormone Signaling
Multiple Choice
In the context of lipid hormone signaling, which of the following is a peptide hormone (as opposed to a lipid-derived steroid/eicosanoid)?
A
Cortisol
B
Estradiol
C
Prostaglandin E (PGE)
D
Insulin
Verified step by step guidance1
Step 1: Understand the classification of hormones based on their chemical nature. Hormones can be broadly categorized into peptide hormones and lipid-derived hormones (such as steroid hormones and eicosanoids).
Step 2: Identify the chemical nature of each hormone listed: Cortisol and Estradiol are steroid hormones derived from cholesterol, Prostaglandin E2 (PGE2) is an eicosanoid derived from fatty acids, and Insulin is a peptide hormone composed of amino acids.
Step 3: Recall that peptide hormones are synthesized as polypeptides or proteins and act by binding to cell surface receptors, whereas steroid and eicosanoid hormones are lipid-soluble and typically bind to intracellular receptors.
Step 4: Compare the options and recognize that Insulin is the only hormone in the list that is a peptide hormone, while the others are lipid-derived.
Step 5: Conclude that Insulin is the correct answer because it is a peptide hormone, distinguishing it from the lipid-derived steroid and eicosanoid hormones listed.
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