Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

8. Protein Function

Hemoglobin Cooperativity

Biochemistry

8. Protein Function

Hemoglobin Cooperativity

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Multiple Choice

Which of the following molecules alters the oxygen affinity of hemoglobin?

Glucose

Cholesterol

Urea

2,3-Bisphosphoglycerate (2,3-BPG)

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Verified step by step guidance

Understand the role of hemoglobin in oxygen transport: Hemoglobin is a protein in red blood cells responsible for binding oxygen in the lungs and releasing it in tissues. Its oxygen affinity can be modulated by various molecules.

Learn about 2,3-Bisphosphoglycerate (2,3-BPG): 2,3-BPG is a small molecule produced in red blood cells during glycolysis. It binds to hemoglobin and stabilizes the T-state (tense state), which has a lower affinity for oxygen, facilitating oxygen release to tissues.

Compare the listed molecules: Glucose, cholesterol, and urea do not directly interact with hemoglobin to alter its oxygen affinity. Glucose is a sugar used for energy, cholesterol is a lipid involved in membrane structure, and urea is a waste product of nitrogen metabolism.

Recognize the physiological importance of 2,3-BPG: In conditions like high altitude or hypoxia, 2,3-BPG levels increase to enhance oxygen delivery to tissues by reducing hemoglobin's oxygen affinity.

Conclude that 2,3-BPG is the correct answer: Based on its specific interaction with hemoglobin and its role in modulating oxygen affinity, 2,3-BPG is the molecule that alters hemoglobin's oxygen affinity.