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Multiple Choice
Which reaction is catalyzed by the enzyme glucose-6-phosphate isomerase in glycolysis?
A
Conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate
B
Conversion of glucose to glucose-6-phosphate
C
Conversion of phosphoenolpyruvate to pyruvate
D
Conversion of glucose-6-phosphate to fructose-6-phosphate
Verified step by step guidance
1
Step 1: Understand the role of glucose-6-phosphate isomerase in glycolysis. This enzyme catalyzes the isomerization of glucose-6-phosphate to fructose-6-phosphate, which is an essential step in the glycolytic pathway.
Step 2: Recall that glycolysis is the metabolic pathway where glucose is broken down to produce energy. Glucose-6-phosphate isomerase facilitates the rearrangement of the six-carbon sugar molecule from an aldose (glucose-6-phosphate) to a ketose (fructose-6-phosphate).
Step 3: Write the chemical equation for the reaction catalyzed by glucose-6-phosphate isomerase:
Step 4: Recognize that this reaction is reversible and occurs early in glycolysis, after glucose is phosphorylated to glucose-6-phosphate by hexokinase or glucokinase.
Step 5: Eliminate the incorrect options by comparing the enzyme's specific function. Glucose-6-phosphate isomerase does not catalyze the conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate, glucose to glucose-6-phosphate, or phosphoenolpyruvate to pyruvate. Its specific role is the conversion of glucose-6-phosphate to fructose-6-phosphate.