Multiple Choice
Prenylated proteins:
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10. Lipids
Lipid-Linked Membrane Proteins
Multiple Choice
Which of the lipid anchor modification(s) is (are) readily reversible with the help of thioesterases?
A
Myristoylation.
B
Palmitoylation.
C
Glycosyl-phosphatidylinositolation (GPI).
D
All of the above.
E
None of the above.
Verified step by step guidance1
Understand the concept of lipid anchor modifications: These are post-translational modifications that attach lipids to proteins, helping them associate with cell membranes.
Identify the types of lipid anchor modifications mentioned: Myristoylation, Palmitoylation, and Glycosyl-phosphatidylinositolation (GPI).
Recognize that thioesterases are enzymes that can cleave thioester bonds, which are present in certain lipid modifications.
Determine which lipid modification involves thioester bonds: Palmitoylation involves the attachment of a palmitoyl group via a thioester bond to cysteine residues on proteins.
Conclude that Palmitoylation is the lipid anchor modification that is readily reversible with the help of thioesterases, as thioesterases can specifically cleave the thioester bond in palmitoylated proteins.
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