Multiple Choice
Which of the following lipid-linked proteins are located primarily on the exterior surface of the membrane?
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10. Lipids
Lipid-Linked Membrane Proteins
Multiple Choice
Prenylated proteins:
A
Are integral membrane proteins.
B
Contain amide linkages to straight-chain fatty acids.
C
Contain ester linkages to straight-chain fatty acids.
D
Are post-translationally modified proteins.
E
None of the above.
Verified step by step guidance1
Understand the concept of prenylation: Prenylation is a type of post-translational modification where hydrophobic molecules, such as farnesyl or geranylgeranyl groups, are added to proteins. This modification helps anchor proteins to cell membranes.
Evaluate option a: Integral membrane proteins are proteins that are permanently attached to the membrane. While prenylation helps proteins associate with membranes, it does not make them integral membrane proteins.
Evaluate option b: Amide linkages involve a bond between a carboxyl group and an amine group. Prenylation does not involve amide linkages to straight-chain fatty acids.
Evaluate option c: Ester linkages involve a bond between a carboxyl group and an alcohol group. Prenylation does not involve ester linkages to straight-chain fatty acids.
Evaluate option d: Recognize that prenylated proteins are indeed post-translationally modified, as prenylation occurs after the protein is synthesized. This modification is crucial for the protein's function and localization.
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