Multiple Choice
Prenylated proteins:
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10. Lipids
Lipid-Linked Membrane Proteins
Multiple Choice
Which of the following lipid-linked proteins are located primarily on the exterior surface of the membrane?
A
Prenylated proteins.
B
Myristoylated proteins.
C
Plamitoylated proteins.
D
GPI-linked proteins.
E
Farnesyl-linked proteins.
Verified step by step guidance1
Understand the types of lipid modifications that can anchor proteins to membranes. These include prenylation, myristoylation, palmitoylation, and glycosylphosphatidylinositol (GPI) anchoring.
Recognize that GPI-anchored proteins are unique because they are attached to the membrane via a glycosylphosphatidylinositol moiety, which is a glycolipid that anchors proteins to the exterior surface of the plasma membrane.
Differentiate between the locations of these lipid modifications: Prenylated, myristoylated, and palmitoylated proteins are typically found on the cytoplasmic side of the membrane, whereas GPI-anchored proteins are found on the extracellular side.
Recall that GPI anchors are added to proteins in the endoplasmic reticulum and are directed to the outer leaflet of the plasma membrane, making them accessible to the extracellular environment.
Conclude that among the options provided, GPI-linked proteins are the ones primarily located on the exterior surface of the membrane.
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