Multiple Choice
In eukaryotic cells, where does glycolysis take place?
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Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Glycolysis 1
Multiple Choice
Which of the following statements about glycolysis is true?
A
Glycolysis occurs in the cytosol and can proceed in the absence of oxygen.
B
Glycolysis occurs in the mitochondrial matrix and requires oxygen directly as a substrate.
C
The net energy yield of glycolysis is 4 ATP and 2 NADH per glucose.
D
Glycolysis converts 1 glucose into 2 acetyl-CoA as its final products.
Verified step by step guidance1
Step 1: Understand the location and oxygen requirement of glycolysis. Glycolysis is a metabolic pathway that breaks down glucose into pyruvate and occurs in the cytosol (the fluid part of the cytoplasm). It does not require oxygen directly, meaning it can proceed under anaerobic conditions.
Step 2: Review the energy yield of glycolysis. Glycolysis produces a net gain of 2 ATP molecules per glucose molecule, not 4 ATP. Although 4 ATP are produced, 2 ATP are consumed during the early steps, resulting in a net gain of 2 ATP. Additionally, glycolysis produces 2 NADH molecules per glucose.
Step 3: Examine the final products of glycolysis. The pathway converts one glucose molecule into two molecules of pyruvate, not acetyl-CoA. The conversion of pyruvate to acetyl-CoA occurs later in the mitochondria during the link reaction (pyruvate oxidation).
Step 4: Analyze the incorrect statement about glycolysis occurring in the mitochondrial matrix and requiring oxygen. Glycolysis takes place in the cytosol, not the mitochondrial matrix, and it does not require oxygen directly as a substrate.
Step 5: Conclude that the true statement is: Glycolysis occurs in the cytosol and can proceed in the absence of oxygen.
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