Multiple Choice
In eukaryotic cells, where does glycolysis take place?
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Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Glycolysis 1
Multiple Choice
During glycolysis of one molecule of glucose, what is the net gain of ATP produced by substrate-level phosphorylation (ATP produced minus ATP consumed)?
A
6 ATP
B
2 ATP
C
0 ATP
D
4 ATP
Verified step by step guidance1
Recall that glycolysis is the metabolic pathway that converts one molecule of glucose into two molecules of pyruvate, producing ATP and NADH in the process.
Identify the steps in glycolysis where ATP is consumed: ATP is used in the phosphorylation of glucose to glucose-6-phosphate and in the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. This accounts for 2 ATP molecules consumed.
Identify the steps in glycolysis where ATP is produced by substrate-level phosphorylation: ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate and when phosphoenolpyruvate is converted to pyruvate. Since each of these steps occurs twice per glucose molecule (because glucose splits into two triose phosphates), a total of 4 ATP molecules are produced.
Calculate the net ATP gain by subtracting the ATP consumed from the ATP produced: Net ATP = ATP produced - ATP consumed.
Express the net gain explicitly as: Net ATP = 4 ATP (produced) - 2 ATP (consumed) = 2 ATP.
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