Multiple Choice
In glycolysis, ATP molecules are produced directly by which process?
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Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Glycolysis 2
Multiple Choice
In glycolysis, which molecule is oxidized during the glyceraldehyde-3-phosphate dehydrogenase reaction?
A
NADH is oxidized to
B
Glyceraldehyde-3-phosphate is oxidized to 1,3-bisphosphoglycerate
C
Pyruvate is oxidized to acetyl-
D
is oxidized to −
Verified step by step guidance1
Identify the reactants and products involved in the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) reaction in glycolysis. This enzyme catalyzes the conversion of glyceraldehyde-3-phosphate (G3P) to 1,3-bisphosphoglycerate (1,3-BPG).
Understand the concept of oxidation and reduction in biochemical reactions: oxidation involves the loss of electrons (or hydrogen atoms), while reduction involves the gain of electrons.
Recognize that during the GAPDH reaction, glyceraldehyde-3-phosphate loses electrons and is therefore oxidized, while NAD+ gains electrons and is reduced to NADH.
Write the overall reaction catalyzed by GAPDH: \$\(\text{Glyceraldehyde-3-phosphate}\) + \(\text{NAD}\)^+ + \(\text{Pi}\) \(\rightarrow\) \(\text{1,3-bisphosphoglycerate}\) + \(\text{NADH}\) + \(\text{H}\)^+\$
Conclude that glyceraldehyde-3-phosphate is the molecule oxidized in this reaction, as it donates electrons to NAD+, which is reduced to NADH.
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