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Multiple Choice
The strong negative charges of DNA come from which of the following groups?
A
Hydroxyl groups
B
Nitrogenous bases
C
Deoxyribose sugars
D
Phosphate groups
Verified step by step guidance
1
Understand the structure of DNA: DNA is composed of nucleotides, each consisting of a phosphate group, a deoxyribose sugar, and a nitrogenous base.
Recognize the role of phosphate groups: Phosphate groups are part of the DNA backbone and are negatively charged due to the presence of oxygen atoms bonded to phosphorus, which can lose protons (H⁺) in aqueous solutions.
Eliminate incorrect options: Hydroxyl groups are present in the sugar but do not contribute strong negative charges. Nitrogenous bases are involved in base pairing but are not negatively charged. Deoxyribose sugars are neutral and do not contribute to the negative charge.
Focus on the phosphate groups: The negative charges of DNA arise specifically from the phosphate groups in the backbone, which are ionized under physiological conditions.
Conclude: The strong negative charges of DNA come from the phosphate groups, which are essential for the molecule's structural integrity and interactions with positively charged molecules like histones.