Multiple Choice
The expression of a gene located in a tightly coiled region of DNA can be promoted by __________.
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16. Regulation of Expression
Eukaryotic Chromatin Modifications
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Histone modifications can result in which of the following effects on gene expression?
A
Complete deletion of genes
B
Permanent alteration of DNA sequence
C
Inhibition of protein synthesis
D
Activation of gene expression
Verified step by step guidance1
Understand that histone modifications are chemical changes to the proteins around which DNA is wound, affecting how tightly or loosely DNA is packaged.
Recognize that these modifications do not alter the DNA sequence itself but can influence gene expression by changing the accessibility of the DNA to transcription machinery.
Consider that when histones are acetylated, the chromatin structure becomes more open, allowing transcription factors to access the DNA and potentially activate gene expression.
Note that histone methylation can either activate or repress gene expression depending on the specific amino acids in the histone proteins that are methylated and the number of methyl groups added.
Conclude that histone modifications can lead to activation of gene expression by making the DNA more accessible for transcription, rather than deleting genes, altering DNA sequences, or directly inhibiting protein synthesis.
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