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Multiple Choice
Which of the following is the primary way that carbon dioxide (CO$_2$) is transported in the blood from body tissues to the lungs?
A
Dissolved directly as CO$_2$ gas in plasma
B
As carbonic acid (H$_2$CO$_3$) in red blood cells
C
As bicarbonate ions (HCO$_3^-$) dissolved in plasma
D
Bound to the heme group of hemoglobin
Verified step by step guidance
1
Understand the context: Carbon dioxide (CO$_2$) is a waste product of cellular respiration and must be transported from body tissues to the lungs for exhalation. The question asks about the primary mechanism of CO$_2$ transport in the blood.
Recall the three main ways CO$_2$ is transported in the blood: (1) dissolved directly as CO$_2$ gas in plasma, (2) bound to hemoglobin (carbaminohemoglobin), and (3) converted to bicarbonate ions (HCO$_3^-$) in plasma.
Focus on the primary mechanism: The majority of CO$_2$ is transported as bicarbonate ions (HCO$_3^-$). This occurs through a chemical reaction catalyzed by the enzyme carbonic anhydrase in red blood cells. The reaction is: CO$_2$ + H$_2$O ⇌ H$_2$CO$_3$ ⇌ H$^+$ + HCO$_3^-$.
Explain the process: Inside red blood cells, CO$_2$ reacts with water (H$_2$O) to form carbonic acid (H$_2$CO$_3$), which quickly dissociates into hydrogen ions (H$^+$) and bicarbonate ions (HCO$_3^-$). The bicarbonate ions then diffuse into the plasma, where they are transported to the lungs.
Summarize why this is the primary mechanism: While some CO$_2$ is transported dissolved in plasma or bound to hemoglobin, the majority (approximately 70%) is transported as bicarbonate ions in plasma, making this the primary method of CO$_2$ transport in the blood.