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Multiple Choice
Which of the following is most likely to cause the hypothalamus to increase production of gonadotropin-releasing hormone (GnRH)?
A
Increased melatonin secretion
B
High levels of luteinizing hormone (LH)
C
Low circulating levels of sex steroids (e.g., estrogen or testosterone)
D
Elevated blood glucose levels
Verified step by step guidance
1
Understand the role of the hypothalamus in regulating reproductive hormones. The hypothalamus produces gonadotropin-releasing hormone (GnRH), which stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones are involved in regulating the production of sex steroids like estrogen and testosterone.
Recognize the feedback mechanism in the endocrine system. Low circulating levels of sex steroids (e.g., estrogen or testosterone) signal the hypothalamus to increase GnRH production to restore balance. This is an example of negative feedback regulation.
Evaluate the other options provided in the question. Increased melatonin secretion is associated with sleep regulation and seasonal reproductive cycles in some animals, but it does not directly stimulate GnRH production. High levels of LH would typically indicate sufficient GnRH activity, so the hypothalamus would not need to increase GnRH production. Elevated blood glucose levels are related to energy metabolism and do not directly affect GnRH production.
Focus on the correct answer: Low circulating levels of sex steroids. When sex steroid levels drop, the hypothalamus detects this and increases GnRH production to stimulate the pituitary gland, which in turn promotes the production of sex steroids by the gonads.
Summarize the physiological process: The hypothalamus responds to low levels of sex steroids by increasing GnRH production, which helps restore hormonal balance through the stimulation of LH and FSH release from the pituitary gland.