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Multiple Choice
Why is a membrane receptor not needed for hormones such as estrogen and testosterone?
A
Because they are lipid-soluble and can diffuse directly through the plasma membrane to bind intracellular receptors.
B
Because they only act on cells that lack any type of receptor.
C
Because they are broken down before reaching the cell membrane.
D
Because they are too large to interact with membrane-bound receptors.
Verified step by step guidance
1
Understand the nature of estrogen and testosterone: These hormones are classified as steroid hormones, which are derived from lipids (cholesterol). Their lipid-soluble nature is key to their ability to interact with cells.
Recall the structure of the plasma membrane: The plasma membrane is composed of a phospholipid bilayer, which is selectively permeable. Lipid-soluble molecules can easily diffuse through this bilayer without the need for membrane-bound receptors.
Learn about intracellular receptors: Once lipid-soluble hormones like estrogen and testosterone diffuse through the plasma membrane, they bind to specific intracellular receptors located in the cytoplasm or nucleus of the target cell.
Understand the mechanism of action: After binding to intracellular receptors, these hormone-receptor complexes often act as transcription factors, directly influencing gene expression by binding to DNA and regulating the production of specific proteins.
Eliminate incorrect options: The other choices can be ruled out because (1) these hormones do act on cells with specific intracellular receptors, (2) they are not broken down before reaching the cell membrane, and (3) their size does not prevent interaction with receptors, as their lipid-solubility is the determining factor.