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Multiple Choice
Which of the following genes could be classified as a proto-oncogene?
A
RB1
B
p53
C
Ras
D
BRCA1
Verified step by step guidance
1
Understand the definition of a proto-oncogene: Proto-oncogenes are normal genes that, when mutated or expressed at high levels, can become oncogenes, which contribute to cancer development.
Identify the role of each gene listed: RB1 and p53 are known as tumor suppressor genes, which help prevent uncontrolled cell growth. BRCA1 is also a tumor suppressor gene involved in DNA repair.
Recognize the characteristics of Ras: Ras is a gene that encodes a protein involved in cell signal transduction. When mutated, it can lead to uncontrolled cell division, classifying it as a proto-oncogene.
Differentiate between proto-oncogenes and tumor suppressor genes: Proto-oncogenes promote cell growth and division, while tumor suppressor genes inhibit it. Mutations in proto-oncogenes can lead to cancer, whereas mutations in tumor suppressor genes can prevent them from stopping cancer.
Conclude that Ras is the gene that fits the definition of a proto-oncogene, as it can lead to cancer when mutated or overexpressed.