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Multiple Choice
What is necessary for a cell to pass the G2 checkpoint during the cell cycle?
A
Increase in cell size
B
Activation of cyclin-dependent kinases
C
Attachment of chromosomes to spindle fibers
D
Completion of DNA replication
Verified step by step guidance
1
Understand the role of the G2 checkpoint in the cell cycle. The G2 checkpoint ensures that the cell is ready to enter mitosis (M phase) by checking for DNA damage and confirming that DNA replication is complete.
Recognize that the completion of DNA replication is crucial for a cell to pass the G2 checkpoint. This ensures that the cell has two complete sets of DNA, necessary for cell division.
Learn about cyclin-dependent kinases (CDKs) and their role in the cell cycle. CDKs are enzymes that, when activated, help regulate the progression of the cell cycle, including the transition from G2 to M phase.
Understand the importance of cell size increase. While cell size is monitored, the primary requirement for passing the G2 checkpoint is the completion of DNA replication.
Note that the attachment of chromosomes to spindle fibers is a requirement for the metaphase checkpoint, not the G2 checkpoint. The G2 checkpoint focuses on DNA replication and damage repair.