Multiple Choice
What is the primary purpose of checkpoints in the cell cycle?
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11. Cell Division
Cell Cycle Regulation
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Which enzymes are primarily responsible for controlling the progression of cells through the cell cycle checkpoints?
A
Topoisomerases
B
Ligases
C
Cyclin-dependent kinases (CDKs)
D
DNA polymerases
Verified step by step guidance1
Understand the role of cell cycle checkpoints: Cell cycle checkpoints are control mechanisms in eukaryotic cells which ensure proper division of the cell. They prevent the cell from progressing to the next phase until certain conditions are met.
Identify the key enzymes involved in cell cycle regulation: Cyclin-dependent kinases (CDKs) are the primary enzymes that regulate the cell cycle. They are activated by binding to cyclins, which are proteins whose levels fluctuate throughout the cell cycle.
Differentiate between the enzymes listed: Topoisomerases are involved in DNA replication and help relieve the strain while double-stranded DNA is being unwound. Ligases are enzymes that facilitate the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. DNA polymerases are responsible for DNA synthesis.
Focus on the function of CDKs: Cyclin-dependent kinases (CDKs) control the progression of cells through the cell cycle by phosphorylating target proteins. This phosphorylation triggers the necessary changes in the cell cycle machinery.
Conclude why CDKs are the correct answer: Given their role in regulating the cell cycle by ensuring that each phase is completed accurately before moving on to the next, CDKs are the enzymes primarily responsible for controlling the progression of cells through the cell cycle checkpoints.
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