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Multiple Choice
Which type of protein is typically translated by a ribosome bound to the rough endoplasmic reticulum (RER)?
A
Cytosolic proteins
B
Nuclear proteins
C
Secretory proteins
D
Mitochondrial proteins
Verified step by step guidance
1
Understand the role of the rough endoplasmic reticulum (RER) in protein synthesis. The RER is studded with ribosomes and is primarily involved in the synthesis of proteins destined for secretion, incorporation into the cell membrane, or for use in lysosomes.
Recognize the types of proteins synthesized by ribosomes bound to the RER. These ribosomes translate mRNA into proteins that are typically secretory, membrane-bound, or lysosomal proteins.
Differentiate between proteins synthesized by free ribosomes and those synthesized by ribosomes bound to the RER. Free ribosomes in the cytosol generally synthesize proteins that function within the cytosol, nucleus, or mitochondria.
Identify the signal sequence that directs ribosomes to the RER. Proteins destined for secretion or for the RER have a signal peptide that directs the ribosome to the RER, where translation continues.
Conclude that secretory proteins are typically translated by ribosomes bound to the RER, as they require processing and transport through the endomembrane system for secretion outside the cell.