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Multiple Choice
Which of the following best describes the sequence of ion movements during the depolarization phase of an action potential in a neuron?
A
Voltage-gated K$^+$ channels open, allowing K$^+$ to enter the cell.
B
Na$^+$/K$^+$ pumps actively transport Na$^+$ into the cell and K$^+$ out of the cell.
C
Voltage-gated Na$^+$ channels open, allowing Na$^+$ to enter the cell.
D
Cl$^-$ channels open, allowing Cl$^-$ to leave the cell.
Verified step by step guidance
1
Understand the concept of an action potential: An action potential is a rapid change in the electrical charge across a neuron's membrane, allowing the neuron to transmit signals. It involves depolarization, repolarization, and a return to resting potential.
Focus on the depolarization phase: During depolarization, the inside of the neuron becomes less negative (more positive) compared to the outside. This is primarily due to the movement of ions across the membrane.
Identify the key ion movement during depolarization: Voltage-gated Na$^+$ channels open in response to a stimulus, allowing Na$^+$ ions to flow into the cell down their electrochemical gradient. This influx of positively charged Na$^+$ ions causes the membrane potential to become more positive.
Clarify why other options are incorrect: Voltage-gated K$^+$ channels are involved in repolarization, not depolarization. The Na$^+$/K$^+$ pump maintains resting potential but does not directly contribute to depolarization. Cl$^-$ channels are not involved in depolarization in this context.
Summarize the correct answer: The depolarization phase of an action potential is best described by the opening of voltage-gated Na$^+$ channels, allowing Na$^+$ ions to enter the cell and make the membrane potential more positive.