Multiple Choice
What is the effect of a nucleotide-pair substitution that results in a nonsense mutation in a gene?
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15. Gene Expression
Mutations
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Which type of mutation results in the premature termination of translation of an mRNA molecule?
A
Nonsense mutation
B
Frameshift mutation
C
Missense mutation
D
Silent mutation
Verified step by step guidance1
Understand the process of translation: Translation is the process by which the ribosome reads the mRNA sequence and synthesizes a corresponding protein by linking amino acids together.
Learn about mutations: Mutations are changes in the nucleotide sequence of DNA, which can affect the mRNA and subsequently the protein produced.
Identify the types of mutations: Nonsense, frameshift, missense, and silent mutations are different types of mutations that can affect protein synthesis.
Focus on nonsense mutations: A nonsense mutation introduces a premature stop codon in the mRNA sequence, leading to the early termination of translation and resulting in a truncated, nonfunctional protein.
Compare with other mutations: Frameshift mutations alter the reading frame, missense mutations change one amino acid, and silent mutations do not affect the protein sequence. Only nonsense mutations lead to premature termination of translation.
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