Multiple Choice
Which type of mutation results in the premature termination of translation of an mRNA molecule?
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15. Gene Expression
Mutations
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Which of the following is an example of a frameshift mutation?
A
Substitution of one nucleotide for another
B
Insertion of a single nucleotide
C
Duplication of a gene segment
D
Inversion of a chromosome segment
Verified step by step guidance1
Understand the concept of a frameshift mutation: A frameshift mutation occurs when nucleotides are inserted or deleted from the DNA sequence, causing a shift in the reading frame of the genetic code.
Identify the options given: Substitution of one nucleotide, insertion of a single nucleotide, duplication of a gene segment, and inversion of a chromosome segment.
Analyze each option: A substitution changes one nucleotide for another, which does not shift the reading frame. Duplication and inversion involve larger segments and do not necessarily affect the reading frame.
Focus on the insertion of a single nucleotide: Inserting a nucleotide into the DNA sequence shifts the reading frame, altering the downstream amino acid sequence during translation.
Conclude that the insertion of a single nucleotide is an example of a frameshift mutation, as it changes the reading frame of the genetic code.
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