Multiple Choice
What did researchers discover about the genetic mutation causing the loss of pelvic spines in certain fish populations?
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15. Gene Expression
Mutations
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Which of the following would occur from a mutation in the gene's promoter region?
A
A frameshift mutation in the coding sequence
B
The addition of a poly-A tail to the mRNA
C
Altered transcription levels of the gene
D
A change in the amino acid sequence of the protein
Verified step by step guidance1
Understand that the promoter region of a gene is a sequence of DNA needed to turn a gene on or off. It is located near the transcription start site of the gene and is crucial for the initiation of transcription.
Recognize that mutations in the promoter region do not directly affect the coding sequence of the gene, so they do not cause frameshift mutations or changes in the amino acid sequence of the protein.
Consider that the addition of a poly-A tail is a post-transcriptional modification that occurs after the mRNA is synthesized, and is not directly influenced by mutations in the promoter region.
Focus on the role of the promoter in regulating transcription. A mutation in the promoter region can affect the binding of transcription factors and RNA polymerase, leading to altered transcription levels of the gene.
Conclude that the most likely outcome of a mutation in the promoter region is a change in the rate of transcription, which can result in either increased or decreased levels of mRNA and, consequently, the protein product.
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