14. DNA Synthesis

What is the basis for the difference in how the leading and lagging strands of DNA molecules are synthesized?

a. The origins of replication occur only at the 5′ end.

b. Helicases and single-strand binding proteins work at the 5′ end.

c. DNA polymerase can join new nucleotides only to the 3′ end of a pre-existing strand, and the strands are antiparallel.

d. DNA ligase works only in the 3′→5′ direction.

How are Okazaki fragments synthesized?

a. By using the leading-strand template, and synthesizing 5'→3'

b. By using the leading-strand template, and synthesizing 3'→5'

c. By using the lagging-strand template, and synthesizing 5'→3'

d. By using the lagging-strand template, and synthesizing 3'→5'.

The elongation of the leading strand during DNA synthesis

a. Progresses away from the replication fork

b. Occurs in the 3′→5′ direction

c. Produces Okazaki fragments

d. Depends on the action of DNA polymerase