In the context of control of the cell cycle, which proteins stimulate cell division by activating cyclin-dependent kinases (CDKs) to promote progression through checkpoints?

Know that cyclins bind to CDKs, causing a conformational change that activates the kinase activity of CDKs, enabling them to phosphorylate substrates necessary for cell cycle progression.

Identify that integrins, histones, and tubulins have different cellular roles: integrins are involved in cell adhesion, histones package DNA, and tubulins form microtubules, none of which directly activate CDKs.