Multiple Choice
How does DNA ligase function during DNA replication?
2
views
17. Mutation, Repair, and Recombination
DNA Repair
Struggling with Genetics?
Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
What is the role of DNA ligase in DNA replication?
A
It removes mismatched nucleotides during proofreading.
B
It synthesizes RNA primers to initiate DNA synthesis.
C
It joins Okazaki fragments by forming phosphodiester bonds between DNA fragments on the lagging strand.
D
It unwinds the DNA double helix to allow replication to occur.
Verified step by step guidance1
Understand that DNA replication involves multiple enzymes, each with a specific role in copying the DNA accurately and efficiently.
Recall that DNA ligase is an enzyme responsible for joining DNA fragments together, specifically on the lagging strand where short DNA pieces called Okazaki fragments are synthesized.
Recognize that DNA ligase forms phosphodiester bonds, which are the covalent bonds linking the sugar-phosphate backbone of DNA, thereby sealing the gaps between Okazaki fragments.
Differentiate DNA ligase's role from other enzymes: for example, DNA polymerase synthesizes DNA, helicase unwinds the DNA helix, and primase synthesizes RNA primers.
Conclude that the primary role of DNA ligase in DNA replication is to join Okazaki fragments by forming phosphodiester bonds, ensuring the lagging strand becomes a continuous DNA strand.
Related Videos
Related Practice
