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1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

DNA Repair

Genetics

17. Mutation, Repair, and Recombination

DNA Repair

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Multiple Choice

How accurate is DNA replication in eukaryotic cells under normal conditions?

Approximately 1 error per 10^6 nucleotides incorporated

Approximately 1 error per 10^4 nucleotides incorporated

Approximately 1 error per 10^2 nucleotides incorporated

Approximately 1 error per 10^9 nucleotides incorporated

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Verified step by step guidance

Understand that DNA replication accuracy depends on multiple factors including the inherent fidelity of DNA polymerases, proofreading activity, and mismatch repair mechanisms.

Recall that the initial error rate of DNA polymerase without proofreading is about 1 error per 10^5 to 10^6 nucleotides incorporated.

Consider that the 3' to 5' exonuclease proofreading activity of DNA polymerase reduces the error rate by about 100-fold, improving accuracy significantly.

Account for the mismatch repair system, which further corrects errors missed by proofreading, reducing the error rate by another 100-fold.

Combine these factors to understand that the overall error rate in eukaryotic DNA replication under normal conditions is approximately 1 error per 10^9 nucleotides incorporated.