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Multiple Choice
What is the role of DNA ligase during DNA replication?
A
It proofreads newly synthesized DNA strands for errors.
B
It synthesizes RNA primers required for DNA polymerase activity.
C
It joins Okazaki fragments by forming phosphodiester bonds between adjacent DNA nucleotides.
D
It unwinds the DNA double helix to initiate replication.
Verified step by step guidance
1
Understand that DNA replication involves synthesizing new strands complementary to the original DNA strands.
Recognize that the lagging strand is synthesized discontinuously in short segments called Okazaki fragments.
Know that these Okazaki fragments need to be joined together to form a continuous DNA strand.
Identify the enzyme responsible for joining these fragments by forming phosphodiester bonds between adjacent nucleotides, which is DNA ligase.
Conclude that DNA ligase's role is to seal the gaps between Okazaki fragments, ensuring the integrity and continuity of the newly synthesized DNA strand.