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1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

DNA Repair

Genetics

17. Mutation, Repair, and Recombination

DNA Repair

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Multiple Choice

Which of the following statements best describes what happens during mismatch repair of DNA?

The newly synthesized DNA strand is recognized, and the incorrect nucleotide is removed and replaced with the correct one.

Thymine dimers are removed by excising a short single-stranded DNA segment containing the lesion.

Damaged bases are directly repaired by reversing the chemical modification without removing the base.

Double-strand breaks are repaired by joining the broken ends together without using a template.

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Verified step by step guidance

Understand that mismatch repair is a DNA repair mechanism that corrects errors introduced during DNA replication, specifically base-base mismatches and insertion-deletion loops.

Recognize that the repair system must distinguish the newly synthesized strand from the original template strand to know which nucleotide is incorrect.

Know that the repair process involves excising a segment of the newly synthesized DNA strand containing the mismatched nucleotide.

After excision, DNA polymerase fills in the gap by adding the correct nucleotides complementary to the template strand.

Finally, DNA ligase seals the remaining nick in the sugar-phosphate backbone to complete the repair.