Textbook Question
What would be the effects on DNA replication if mutation of DNA pol III caused it to lose each of the following activities?
3′ to 5′ exonuclease activity
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8. DNA Replication
Overview of DNA Replication
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After eukaryotic DNA replication, which of the following statements is correct regarding the resulting DNA molecules?
A
Each DNA molecule consists of one parental strand and one newly synthesized strand.
B
The original DNA molecule remains unchanged, and two new molecules are formed separately.
C
Each DNA molecule contains two parental strands.
D
Both DNA molecules are composed entirely of newly synthesized strands.
Verified step by step guidance1
Recall the semiconservative model of DNA replication, which states that each new DNA molecule consists of one original (parental) strand and one newly synthesized strand.
Understand that during replication, the double helix unwinds and each parental strand serves as a template for the synthesis of a complementary new strand.
Recognize that the original DNA molecule does not remain intact as a whole; instead, it separates into two single strands that are used to form two new double helices.
Eliminate options that suggest both strands are either parental or newly synthesized, as this contradicts the semiconservative nature of replication.
Conclude that the correct statement is that each DNA molecule after replication consists of one parental strand and one newly synthesized strand.
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