Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

8. DNA Replication

Overview of DNA Replication

Genetics

8. DNA Replication

Overview of DNA Replication

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Multiple Choice

Which types of cells have more than one origin of replication during DNA replication?

Prokaryotic cells

Archaeal cells

Eukaryotic cells

Bacterial cells

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Understand the concept of origin of replication: It is the specific sequence in a genome where DNA replication begins.

Recall that prokaryotic cells (including bacterial cells) typically have a single circular chromosome and usually only one origin of replication.

Recognize that archaeal cells, although prokaryotic, can have multiple origins of replication, but this is less common and varies among species.

Know that eukaryotic cells have large linear chromosomes and require multiple origins of replication to efficiently replicate their entire genome within a reasonable time.

Conclude that cells with more than one origin of replication during DNA replication are eukaryotic cells, due to their complex and large genomes.

5:02m

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Related Practice

Textbook Question

What would be the effects on DNA replication if mutation of DNA pol III caused it to lose each of the following activities?

5' to 3' polymerase activity

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Textbook Question

Suppose that future exploration of polar ice on Mars identifies a living microbe and that analysis indicates the organism carries double-stranded DNA as its genetic material. Suppose further that DNA replication analysis is performed by first growing the microbe in a growth medium containing the heavy isotope of nitrogen (¹⁴N) that the organism is then transferred to a growth medium containing the light isotope of nitrogen (¹⁴N) and that the nitrogen composition of the DNA is examined by CsCl ultracentrifugation and densitometry after the first, second, and third replication cycles in the ¹⁴N-containing medium. The results of the experiment are illustrated here for each cycle. The control shows the positioning of the three possible DNA densities. Based on the results shown, what can you conclude about the mechanism of DNA replication in this organism?

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Textbook Question

The following diagram shows the parental strands of a DNA molecule undergoing replication.

Draw the daughter strands present in the replication bubble, indicating:

a. The polarity of daughter strands

b. The leading and lagging strands

c. Okazaki fragments

d. The locations of RNA primers

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Multiple Choice