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Multiple Choice
Which enzyme is responsible for joining DNA fragments during DNA repair?
A
Topoisomerase
B
DNA ligase
C
DNA polymerase
D
Helicase
Verified step by step guidance
1
Understand the role of each enzyme listed in the problem: Topoisomerase, DNA ligase, DNA polymerase, and Helicase.
Recall that DNA ligase is the enzyme responsible for joining DNA fragments by forming phosphodiester bonds between adjacent nucleotides, especially during DNA repair and replication.
Recognize that Topoisomerase helps relieve the tension in DNA strands by cutting and rejoining DNA to prevent supercoiling, but it does not join fragments in repair.
Know that DNA polymerase synthesizes new DNA strands by adding nucleotides complementary to the template strand but does not join fragments.
Understand that Helicase unwinds the DNA double helix by breaking hydrogen bonds between base pairs, facilitating replication and repair but not joining fragments.