Multiple Choice
In DNA replication, which mechanism primarily helps prevent errors by removing misincorporated nucleotides during DNA synthesis?
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17. Mutation, Repair, and Recombination
DNA Repair
Multiple Choice
In the context of DNA repair and genome stability, which vitamin is most directly associated with supporting DNA synthesis and repair by providing one-carbon units for nucleotide production and methylation reactions?
A
Vitamin C (ascorbic acid)
B
Vitamin A (retinol)
C
Folate (vitamin B9)
D
Vitamin K (phylloquinone)
Verified step by step guidance1
Understand the role of vitamins in DNA synthesis and repair, focusing on their biochemical functions related to nucleotide production and methylation.
Recognize that DNA synthesis requires the formation of nucleotides, which depend on one-carbon units for the synthesis of purines and thymidine (a pyrimidine nucleotide).
Identify that one-carbon units are transferred in metabolic pathways involving folate (vitamin B9), which acts as a carrier of these one-carbon groups essential for nucleotide biosynthesis.
Note that folate is also crucial for methylation reactions, which regulate gene expression and maintain genome stability through DNA methylation.
Conclude that among the listed vitamins, folate (vitamin B9) is the vitamin most directly associated with supporting DNA synthesis and repair by providing one-carbon units.
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