In human gestational development, abnormalities of the closure of the lower part of the mid-face can result in cleft lip, if the lip alone is affected by the closure defect, or in cleft lip and palate (the roof of the mouth), if the closure defect is more extensive. Cleft lip and cleft lip with cleft palate are multifactorial disorders that are threshold traits. A family with a history of either condition has a significantly increased chance of a recurrence of mid-face cleft disorder in comparison with families without such a history. However, the recurrence risk of a mid-face cleft disorder is higher in families with a history of cleft lip with cleft palate than in families with a history of cleft lip alone. Construct a similar explanation of why the recurrence risk of a cleft disorder is higher in families with a history of cleft lip with cleft palate than in families with a history of cleft lip alone.
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
20. Quantitative Genetics
Heritability
Problem 27b
Textbook Question
Answer the following in regard to multifactorial traits in human twins. If the trait is produced with little contribution from genetic variation, what would you expect to see if you compared the concordance rates of MZ twins versus DZ twins? Explain your reasoning.

1
Understand the concept of multifactorial traits: Multifactorial traits are influenced by both genetic and environmental factors. Concordance rates measure the likelihood that both twins exhibit the same trait.
Define MZ (monozygotic) and DZ (dizygotic) twins: MZ twins share nearly 100% of their genetic material, while DZ twins share approximately 50% of their genetic material, similar to regular siblings.
Analyze the role of genetic variation: If the trait has little contribution from genetic variation, it means environmental factors play a dominant role in determining the trait.
Compare concordance rates: Since MZ twins share more genetic material than DZ twins, if genetic variation has minimal influence, the concordance rates for MZ twins and DZ twins would be similar. This is because the trait is primarily determined by environmental factors, which affect both types of twins equally.
Explain reasoning: The similarity in concordance rates arises because the genetic contribution is negligible, and environmental factors are shared to a similar extent by both MZ and DZ twins, especially if they are raised in the same environment.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Concordance Rates
Concordance rates refer to the likelihood that both twins in a pair exhibit the same trait. In studies of twins, these rates are compared between monozygotic (MZ) twins, who share nearly all their genes, and dizygotic (DZ) twins, who share about 50% of their genes. Higher concordance rates in MZ twins compared to DZ twins suggest a genetic influence on the trait, while similar rates indicate that environmental factors may play a more significant role.
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Multifactorial Traits
Multifactorial traits are characteristics influenced by multiple genetic and environmental factors. Unlike single-gene traits, these traits do not follow simple Mendelian inheritance patterns. Examples include height, intelligence, and susceptibility to diseases, where both genetic predispositions and environmental conditions contribute to the final phenotype.
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Genetic Variation
Genetic variation refers to the differences in DNA sequences among individuals, which can influence traits. In the context of the question, if a trait shows little contribution from genetic variation, it implies that environmental factors are more significant in determining the trait's expression. This would likely result in similar concordance rates for MZ and DZ twins, as both sets would be equally affected by shared environmental influences.
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