Which type of chromosomal rearrangement occurs when part of a chromosome breaks off and attaches to a nonhomologous chromosome?

A woman who sought genetic counseling is found to be heterozygous for a chromosomal rearrangement between the second and third chromosomes. Her chromosomes, compared to those in a normal karyotype, are diagrammed to the right. This woman is phenotypically normal. Does this surprise you? Why or why not? Under what circumstances might you expect a phenotypic effect of such a rearrangement?

A normal chromosome and its homolog carrying a paracentric inversion are shown here. The dot (·) represents the centromere.

Normal    ABC • DEFGHIJK

Inversion  abc • djihgfe

Diagram the alignment of chromosomes during prophase I.

From the following list, identify the types of chromosome changes you expect to show phenotypic consequences.

Paracentric inversion

Which of the following represents the chromosomal segregation into gametes after a reciprocal translocation caused by adjacent-1 segregation? N=Normal chromosome T = Tanslocated chromosome

Which of the following ways reciprocal translocated chromosomes are sorted produces viable gametes?

An individual heterozygous for a reciprocal translocation has the following chromosomes. Which chromosomes do the gametes receive after alternative segregation? 

A B • C D E F G                        J K • L M N O P 

A B • C D N O P                       J K • L M E F G 

An individual heterozygous for a reciprocal translocation has the following chromosomes. Which chromosomes do the gametes receive after adjacent-1 segregation? 

A B • C D E F G                J K • L M N O P 

A B • C D N O P               J K • L M E F G