3. Extensions to Mendelian Inheritance

The ABO blood group assorts independently of the rhesus (Rh) blood group and both assort independently of the MN blood group. Three alleles, I^A, I^B and i, occur at the ABO locus. Two alleles, R, a dominant allele producing Rh+, and r, a recessive allele for Rh-, are found at the Rh locus, and codominant alleles M and N occur at the MN locus. Each gene is autosomal.

A child with blood types A, Rh−, and M is born to a woman who has blood types O, Rh−, and MN and a man who has blood types A, Rh+, and M. Determine the genotypes of each parent.

In rats, gene B produces black coat color if the genotype is , but black pigment is not produced if the genotype is bb. At an independent locus, gene D produces yellow pigment if the genotype is D-, but no pigment is produced when the genotype is dd. Production of both pigments results in brown coat color. If neither pigment is produced, coat color is cream. Determine the genotypes of parents of litters with the following phenotype distributions.

9 black, 7 brown

In rats, gene B produces black coat color if the genotype is , but black pigment is not produced if the genotype is bb. At an independent locus, gene D produces yellow pigment if the genotype is D-, but no pigment is produced when the genotype is dd. Production of both pigments results in brown coat color. If neither pigment is produced, coat color is cream. Determine the genotypes of parents of litters with the following phenotype distributions.

3 brown, 3 yellow, 1 black, 1 cream

Syntenic genes can assort independently. Explain this observation.

In rats, gene B produces black coat color if the genotype is , but black pigment is not produced if the genotype is bb. At an independent locus, gene D produces yellow pigment if the genotype is D-, but no pigment is produced when the genotype is dd. Production of both pigments results in brown coat color. If neither pigment is produced, coat color is cream. Determine the genotypes of parents of litters with the following phenotype distributions.

4 brown, 4 black, 4 yellow, 4 cream

In the rats identified in Problem 10, a third independently assorting gene involved in the determination of coat color is the C gene. At this locus, the genotype C– permits expression of pigment from genes B and D. The cc genotype, however, prevents expression of coat color and results in albino rats. For each of the following crosses, determine the expected phenotype ratio of progeny.

BbDdCC×BbDdCC

In the rats identified in Problem 10, a third independently assorting gene involved in the determination of coat color is the C gene. At this locus, the genotype C– permits expression of pigment from genes B and D. The cc genotype, however, prevents expression of coat color and results in albino rats. For each of the following crosses, determine the expected phenotype ratio of progeny.

BbDDCc×BbDdCc

In the rats identified in Problem 10, a third independently assorting gene involved in the determination of coat color is the C gene. At this locus, the genotype C– permits expression of pigment from genes B and D. The cc genotype, however, prevents expression of coat color and results in albino rats. For each of the following crosses, determine the expected phenotype ratio of progeny.

BBDdcc×BbddCc

Strains of petunias come in four pure-breeding colors: white, blue, red, and purple. White petunias are produced when plants synthesize no flower pigment. Blue petunias and red petunias are produced when plants synthesize blue or red pigment only. Purple petunias are produced in plants that synthesize both red and blue pigment (the mixture of red and blue makes purple). Flower-color pigments are synthesized by gene action in two separate pigment-producing biochemical pathways. Pathway I contains gene A that produces an enzyme to catalyze conversion of a colorless pigment designated to blue pigment. In Pathway II, the enzymatic product of gene B converts the colorless pigment designated to red pigment. The two genes assort independently.

True-breeding red petunias are crossed to pure-breeding blue petunias, and all the F₁ progeny have purple flowers. If the F₁ are allowed to self-fertilize and produce the F₂, what is the expected phenotypic distribution of the F₂ progeny? Show your work.

List all the different gametes that are possible from the following genotypes.

AabbCCdd

List all the different gametes that are possible from the following genotypes.

AaBbCcDd

List all the different gametes that are possible from the following genotypes.

AabbCcDD

List all the different gametes that are possible from the following genotypes.

AABbCcDd

Organisms with the genotypes AABbCcDd and AaBbCcDd are crossed. What are the expected proportions of the following progeny?

A–B–ccdd

Organisms with the genotypes AABbCcDd and AaBbCcDd are crossed. What are the expected proportions of the following progeny?

A phenotype identical to either parent