Textbook Question
What nucleic acid subunits are connected in a phosphodiester linkage in a polynucleotide?
26. Nucleic Acids and Protein Synthesis
Phosphodiester Bond Formation
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Draw the following phosphodiester bond based on the given description: A phosphodiester bond that connects the C3’ OH group in the ribose of UMP and the 5’ carbon in the ribose of CMP.
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Verified step by step guidance1
Identify the ribose sugar in UMP and locate the C3' OH group. This is the hydroxyl group attached to the third carbon of the ribose ring.
Identify the ribose sugar in CMP and locate the 5' carbon. This is the carbon at the end of the ribose ring that is not part of the ring itself.
Understand that a phosphodiester bond is formed by linking the phosphate group to the C3' OH of one nucleotide and the 5' carbon of another nucleotide.
Draw the phosphate group as a central phosphorus atom double-bonded to one oxygen and single-bonded to two other oxygens, one of which will form a bond with the C3' OH of UMP.
Connect the remaining oxygen of the phosphate group to the 5' carbon of CMP, completing the phosphodiester linkage between the two ribose sugars.
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