Table of contents

1. Matter and Measurements4h 31m
2. Atoms and the Periodic Table5h 23m
3. Ionic Compounds2h 18m
4. Molecular Compounds2h 18m
5. Classification & Balancing of Chemical Reactions3h 17m
6. Chemical Reactions & Quantities2h 27m
7. Energy, Rate and Equilibrium3h 46m
8. Gases, Liquids and Solids3h 25m
9. Solutions4h 10m
10. Acids and Bases3h 29m
11. Nuclear Chemistry56m
BONUS: Lab Techniques and Procedures1h 38m
BONUS: Mathematical Operations and Functions47m
12. Introduction to Organic Chemistry1h 34m
13. Alkenes, Alkynes, and Aromatic Compounds2h 12m
14. Compounds with Oxygen or Sulfur1h 6m
15. Aldehydes and Ketones1h 1m
16. Carboxylic Acids and Their Derivatives1h 11m
17. Amines39m
18. Amino Acids and Proteins1h 51m
19. Enzymes1h 37m
20. Carbohydrates1h 41m
21. The Generation of Biochemical Energy2h 8m
22. Carbohydrate Metabolism2h 22m
23. Lipids2h 26m
24. Lipid Metabolism1h 45m
25. Protein and Amino Acid Metabolism1h 37m
26. Nucleic Acids and Protein Synthesis2h 54m

25. Protein and Amino Acid Metabolism

Amino Acid Catabolism: Carbon Atoms

GOB Chemistry

25. Protein and Amino Acid Metabolism

Amino Acid Catabolism: Carbon Atoms

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2:17 minutes

Problem 92c

Textbook Question

What metabolic substrate(s) can be produced from the carbon atoms of each of the following amino acids?
c. methionine

Verified step by step guidance

Understand that amino acids can be metabolized into various substrates depending on their structure and the metabolic pathways they enter. Methionine is an amino acid that is both glucogenic and ketogenic.

Recognize that methionine is primarily metabolized into succinyl-CoA, which is an intermediate in the citric acid cycle. This makes methionine a glucogenic amino acid because succinyl-CoA can contribute to glucose production via gluconeogenesis.

Note that methionine can also contribute to the production of acetyl-CoA through its metabolism. Acetyl-CoA is a key substrate for the synthesis of ketone bodies, making methionine partially ketogenic.

Consider the biochemical pathway: Methionine is first converted into homocysteine, which can then enter the transsulfuration pathway or be remethylated back to methionine. The transsulfuration pathway leads to the production of succinyl-CoA.

Summarize that the carbon atoms of methionine can be used to produce succinyl-CoA (glucogenic pathway) and acetyl-CoA (ketogenic pathway), depending on the metabolic conditions and the specific pathway utilized.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Amino Acid Metabolism

Amino acid metabolism involves the biochemical processes that break down amino acids for energy or convert them into other compounds. Each amino acid can be transformed into various metabolic substrates, depending on its structure and the body's needs. Understanding these pathways is crucial for determining what substrates can be derived from specific amino acids.

Methionine Catabolism

Methionine is an essential amino acid that plays a key role in various metabolic pathways, including the synthesis of S-adenosylmethionine (SAMe), a critical methyl donor in numerous methylation reactions. During its catabolism, methionine can be converted into homocysteine and subsequently into other substrates like succinyl-CoA, which can enter the citric acid cycle for energy production.

Metabolic Substrates

Metabolic substrates are molecules that serve as the starting materials for metabolic reactions, providing the necessary components for energy production and biosynthesis. In the context of amino acids, these substrates can include intermediates that enter pathways like the citric acid cycle or gluconeogenesis, ultimately contributing to the body's energy balance and metabolic functions.

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