Textbook Question
What metabolic substrate(s) can be produced from the carbon atoms of each of the following amino acids?
d. phenylalanine
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25. Protein and Amino Acid Metabolism
Amino Acid Catabolism: Carbon Atoms
3:51 minutesProblem 61c
Textbook Question
Name the metabolic substrate(s) that can be produced from the carbon atoms of each of the following amino acids:
c. valine
Verified step by step guidance1
Understand the question: The problem asks us to identify the metabolic substrate(s) that can be produced from the carbon atoms of the amino acid valine. This involves understanding the metabolic pathways of amino acid catabolism.
Recall the metabolic fate of valine: Valine is a branched-chain amino acid (BCAA) that undergoes catabolism primarily in muscle tissue. It is converted into intermediates that enter the citric acid cycle (TCA cycle).
Identify the key steps in valine catabolism: Valine is first transaminated to form α-ketoisovalerate. This intermediate undergoes oxidative decarboxylation to form isobutyryl-CoA.
Determine the final metabolic substrate: Isobutyryl-CoA is further metabolized to form succinyl-CoA, which is an intermediate in the citric acid cycle. Succinyl-CoA can be used for energy production or gluconeogenesis.
Conclude the answer: The carbon atoms of valine are ultimately converted into succinyl-CoA, which is the metabolic substrate produced from valine catabolism.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Amino Acid Metabolism
Amino acid metabolism involves the biochemical processes that break down amino acids for energy or convert them into other compounds. Each amino acid can be transformed into various metabolic substrates, depending on its structure and the pathways available in the organism. Understanding these pathways is crucial for identifying the specific substrates produced from amino acids like valine.
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Valine Catabolism
Valine is a branched-chain amino acid that undergoes catabolism primarily in muscle tissue. The breakdown of valine leads to the production of propionyl-CoA, which can enter the citric acid cycle or be converted into glucose through gluconeogenesis. This process highlights the role of valine not only as a building block for proteins but also as a significant energy source.
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Metabolic Substrates
Metabolic substrates are the molecules that serve as the starting materials for metabolic reactions. In the context of amino acids, these substrates can include intermediates that enter various metabolic pathways, such as the citric acid cycle or gluconeogenesis. Identifying the specific substrates produced from valine is essential for understanding its role in energy metabolism and overall physiological function.
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