Multiple Choice
Why is gene therapy for Severe Combined Immunodeficiency (SCID) often performed as an ex vivo therapy?
29. Heredity
Gene Therapy
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Which of the following is a primary advantage of ex vivo gene therapy over in vivo gene therapy?
A
It allows for direct delivery of genes into the patient's body.
B
It reduces the risk of immune response against the introduced vector.
C
It enables precise control and modification of cells outside the body before reintroduction.
D
It eliminates the need for cell culture and manipulation.
Verified step by step guidance1
Understand the difference between ex vivo and in vivo gene therapy. Ex vivo involves modifying cells outside the body, while in vivo involves direct delivery of genes into the body.
Consider the advantages of ex vivo gene therapy. One key advantage is the ability to precisely control and modify cells outside the body before they are reintroduced.
Evaluate the risk factors associated with gene therapy. Ex vivo gene therapy reduces the risk of immune response against the introduced vector because the cells are modified outside the body.
Recognize that ex vivo gene therapy involves cell culture and manipulation, which allows for detailed control over the genetic modifications.
Conclude that the primary advantage of ex vivo gene therapy is the precise control and modification of cells outside the body, which is not possible with in vivo gene therapy.
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