Table of contents

1. Introduction to Anatomy & Physiology5h 43m
2. Cell Chemistry & Cell Components12h 36m
3. Energy & Cell Processes10h 6m
4. Tissues & Histology10h 3m
5. Integumentary System2h 20m
6. Bones & Skeletal Tissue2h 16m
7. The Skeletal System2h 35m
8. Joints2h 17m
9. Muscle Tissue2h 33m
10. Muscles1h 11m
11. Nervous Tissue and Nervous System1h 35m
12. The Central Nervous System1h 6m
- Introduction to the Central Nervous System
  18m
- The Cerebrum
  48m
13. The Peripheral Nervous System1h 26m
14. The Autonomic Nervous System1h 38m
15. The Special Senses2h 41m
16. The Endocrine System2h 48m
17. The Blood3h 22m
18. The Heart3h 42m
19. The Blood Vessels3h 35m
20. The Lymphatic System3h 16m
21. The Immune System14h 37m
22. The Respiratory System3h 20m
23. The Digestive System2h 5m
24. Metabolism and Nutrition4h 0m
25. The Urinary System2h 39m
26. Fluid and Electrolyte Balance, Acid Base Balance37m
27. The Reproductive System2h 5m
28. Human Development1h 21m
29. Heredity3h 32m

29. Heredity

Gene Therapy

Anatomy & Physiology

29. Heredity

Gene Therapy

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Multiple Choice

What factors must be considered when choosing a vector for a gene therapy trial?

The vector's ability to integrate into the host genome

The vector's ability to replicate independently

The vector's ability to target specific cells

The vector's ability to cause an immune response

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Verified step by step guidance

Understand the purpose of a vector in gene therapy: A vector is used to deliver genetic material into cells. It is crucial to choose a vector that can efficiently and safely deliver the therapeutic gene to the target cells.

Consider the vector's ability to integrate into the host genome: Some vectors, like retroviruses, integrate their genetic material into the host genome, which can provide long-term expression of the therapeutic gene. However, this can also pose risks such as insertional mutagenesis.

Evaluate the vector's ability to replicate independently: Vectors that replicate independently, such as plasmids, may not integrate into the host genome, reducing the risk of insertional mutagenesis but potentially requiring repeated administrations.

Assess the vector's ability to target specific cells: It is important for the vector to have specificity for the target cells to ensure that the therapeutic gene is delivered to the correct location, minimizing off-target effects and maximizing therapeutic efficacy.

Examine the vector's potential to cause an immune response: The immune system may recognize the vector as foreign and mount an immune response, which can reduce the effectiveness of the therapy and pose safety concerns. Choosing a vector with low immunogenicity is crucial for successful gene therapy.