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Multiple Choice
Which of the following does not require the release of a first messenger in signal transduction?
A
Steroid hormone receptors
B
Ion channel-linked receptors
C
Tyrosine kinase receptors
D
G-protein coupled receptors
Verified step by step guidance
1
Understand the concept of signal transduction, which is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, ultimately resulting in a cellular response.
Identify the role of first messengers in signal transduction. First messengers are extracellular signaling molecules, such as hormones or neurotransmitters, that bind to receptors on the cell surface to initiate the signaling cascade.
Examine the different types of receptors listed in the problem: Steroid hormone receptors, Ion channel-linked receptors, Tyrosine kinase receptors, and G-protein coupled receptors.
Recognize that steroid hormone receptors are intracellular receptors. Steroid hormones can pass through the cell membrane without the need for a first messenger because they are lipophilic, meaning they can directly interact with intracellular receptors.
Contrast this with the other receptor types: Ion channel-linked receptors, Tyrosine kinase receptors, and G-protein coupled receptors, which typically require a first messenger to bind to the receptor on the cell surface to initiate signal transduction.