3. Energy & Cell Processes

A cancer cell __________.

In the human genome, oncogenes __________.

Most human cancers are __________.

What gene has been called the "guardian angel of the genome"?

Why is cancer more prevalent in older people?

In what way can cancer be hereditary?

The BRCA1 and BRCA2 genes are thought to be what type of genes?

What two genes are often mutated in colon cancer?

Which of the following accurately characterizes our current understanding of cancer development?

Describe three ways that cancer cells differ from normal cells.

Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related toa. disruption of mitotic spindle formation.b. suppression of cyclin production.c. myosin denaturation and inhibition of cleavage furrow formation.d.inhibition of DNA synthesis.

One difference between cancer cells and normal cells is that cancer cellsa. are unable to synthesize DNA.b. are arrested at the S phase of the cell cycle.c. continue to divide even when they are tightly packed together.d. cannot function properly because they are affected by density-dependent inhibition.

Evaluate each of the following defects. Which could lead to uncontrolled growth in cancer? Select True or False for each statement.T/FThe overexpression of MPF activity.T/FA nonfunctional Rb protein.T/FThe overexpression of G1 cyclin.T/FA nonfunctional E2F protein.

All your cells contain proto-oncogenes, which can change into cancer-causing oncogenes. Why do cells possess such potential time bombs?

Compare and contrast the effects of removing growth factors from asynchronous cultures of human cells that are normal and those that are cancerous.