Multiple Choice
In oxidative phosphorylation, what is the primary role of NADH in cellular respiration?
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Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation
Oxidative Phosphorylation 1
Multiple Choice
In aerobic metabolism of one molecule of glucose in a typical eukaryotic cell, which process produces the greatest amount of ATP directly or indirectly via oxidative phosphorylation?
A
Citric acid cycle (substrate-level phosphorylation at succinyl-CoA synthetase)
B
Glycolysis (substrate-level phosphorylation)
C
Electron transport chain and ATP synthase driven by NADH and FADH oxidation (oxidative phosphorylation)
D
Pyruvate oxidation to acetyl-CoA (via pyruvate dehydrogenase)
Verified step by step guidance1
Step 1: Understand the overall process of aerobic glucose metabolism, which includes glycolysis, pyruvate oxidation, the citric acid cycle, and the electron transport chain coupled with ATP synthase.
Step 2: Identify the ATP yield from substrate-level phosphorylation in glycolysis and the citric acid cycle. Glycolysis produces a small amount of ATP directly, and the citric acid cycle produces a small amount via succinyl-CoA synthetase.
Step 3: Recognize that pyruvate oxidation to acetyl-CoA does not produce ATP directly but generates NADH, which carries electrons to the electron transport chain.
Step 4: Understand that NADH and FADH2 generated in glycolysis, pyruvate oxidation, and the citric acid cycle donate electrons to the electron transport chain, which drives oxidative phosphorylation.
Step 5: Conclude that the electron transport chain and ATP synthase produce the greatest amount of ATP indirectly by using the energy from NADH and FADH2 oxidation to generate a proton gradient that powers ATP synthesis.
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