Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

Biochemistry

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

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Multiple Choice

Which of the following best describes the 'induced fit' model of enzyme-substrate interaction?

The substrate is forced to fit into a rigid, unchanging active site of the enzyme.

The enzyme and substrate do not interact directly; instead, the enzyme acts as a scaffold.

The enzyme changes its shape slightly to better fit the substrate upon binding.

The enzyme and substrate bind through covalent bonds, permanently altering the enzyme.

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Verified step by step guidance

Step 1: Begin by understanding the concept of enzyme-substrate interaction. Enzymes are biological catalysts that speed up chemical reactions by lowering the activation energy. They achieve this by binding to specific substrates at their active sites.

Step 2: Review the 'induced fit' model. This model suggests that the enzyme's active site is flexible and can change its shape slightly to accommodate the substrate more effectively upon binding. This contrasts with the 'lock and key' model, where the active site is rigid and fits the substrate perfectly without any structural change.

Step 3: Analyze the options provided in the problem. Eliminate choices that contradict the induced fit model. For example, the statement 'The substrate is forced to fit into a rigid, unchanging active site of the enzyme' aligns with the lock and key model, not the induced fit model.

Step 4: Consider the correct description of the induced fit model: 'The enzyme changes its shape slightly to better fit the substrate upon binding.' This aligns with the flexibility and adaptability of the enzyme's active site in the induced fit model.

Step 5: Conclude that the induced fit model emphasizes the dynamic nature of enzyme-substrate interaction, where the enzyme adjusts its shape to optimize binding and catalysis, rather than relying on a rigid structure or permanent covalent bonding.