Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

4. Protein Structure

Peptide Bond

Biochemistry

4. Protein Structure

Peptide Bond

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Multiple Choice

Which of the following statements about peptide bonds is true?

Peptide bonds allow free rotation around the C-N bond.

Peptide bonds are nonpolar and do not participate in hydrogen bonding.

Peptide bonds are easily broken by hydrolysis under physiological conditions.

Peptide bonds are formed by a condensation reaction between the amino group of one amino acid and the carboxyl group of another.

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Verified step by step guidance

Step 1: Understand the nature of peptide bonds. Peptide bonds are covalent bonds formed between the amino group (-NH₂) of one amino acid and the carboxyl group (-COOH) of another amino acid. This bond formation involves a condensation reaction, where a molecule of water (H₂O) is released.

Step 2: Analyze the statement about free rotation around the C-N bond. Peptide bonds have partial double-bond character due to resonance between the carbonyl oxygen and the nitrogen. This restricts free rotation around the C-N bond, making the peptide bond planar.

Step 3: Evaluate the statement about polarity and hydrogen bonding. Peptide bonds are polar due to the electronegativity difference between the carbonyl oxygen and the amide nitrogen. This polarity allows peptide bonds to participate in hydrogen bonding, which is crucial for protein secondary and tertiary structures.

Step 4: Assess the statement about hydrolysis under physiological conditions. Peptide bonds are relatively stable under physiological conditions and require enzymatic catalysis (e.g., proteases) for hydrolysis. They are not easily broken without such assistance.

Step 5: Confirm the correct statement. The correct statement is that peptide bonds are formed by a condensation reaction between the amino group of one amino acid and the carboxyl group of another. This is the fundamental process of peptide bond formation during protein synthesis.